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Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons

Work closely with your healthcare provider to monitor symptoms and adjust doses if needed

Mechanisms of disease: inflammatory bowel diseases

PlexusDx providers can recommend timing adjustments, dietary modifications, or over-the-counter remedies to ease the transition

IGF-1 is a primary mediator of growth hormone (GH), with growth-promoting effects on most cells and tissues including skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic, and lung [1]

Results Inhibition of glutathione metabolism depletes neuronal glutamate and affects excitatory transmission To test the hypothesis that glutathione is a significant reservoir for glutamate, we treated neuronal cells with molecular inhibitors targeting enzymes of the glutathione metabolic cycle: L-2-imidazolidone-4-carboxylate (2I4C), acivicin, L-buthionine sulfoximine (BSO), and sulforaphane