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In experimental models, OLETF rats have shown local RAS activation, which resulted in oxidative stress and kidney progressive damage, whereas treatment with dapagliflozin remarkably lowered the urinary ANG II and AGT levels (47)

Cost: prescription medications may carry substantially higher out-of-pocket costs, depending on the specific drug, pharmacy price, insurance coverage, and any manufacturer assistance program

When calorie intake decreases significantly, protein consumption often drops as well

Refer patients who dont respond to lifestyle or pharmacological therapies

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Expect gradual, evidence-driven adjustments rather than abrupt assumption changes