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A cascade involving edema, an inflammatory response, ROS/reactive nitrogen species (RNS) production, glutamate-mediated toxic effects, neuronal apoptosis, ferroptosis, and glial scarring occurs after SCI [31,32,33]
10.1007/s10815-010-9436-1 28
the liposomal format bypasses this breakdown and delivers intact glutathione directly to cells.*
It has been reported that cells in a high mesenchymal or stem state are selectively sensitive to ferroptosis, which is a regulated cell death executed by lipid hydroperoxides ( Figures 3A, B and Supplementary Figures S2AC )
Glutathione peroxidase enzymes are specialized in breaking down hydrogen peroxide (H2O2) and lipid peroxides (ROOH) into harmless water (H2O) and lipid alcohols (ROH), respectively
Vazquez J
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