Inhibition of triggering receptor expressed on myeloid cells 1 (TREM1) has been shown to improve cognitive function in T2DM mice ( Animal studies have demonstrated that overexpression of triggering receptor expressed on myeloid cells 2 (TREM2) in the hippocampus can improve cognitive dysfunction caused by long-term high-fat diets (HFD)
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Newsome P, Francque S, Harrison S, Ratziu V, Van Gaal L, Calanna S, et al
With the advent of recombinant peptide synthesis in the 1970s, scientists not only began working on isolating the gene responsible for insulin production but fabricating it outside the body
This mechanism may also help guide the future development of peptide-based therapeutic injectables for hypertension, cardiovascular risk, endothelial dysfunction, and related cardiometabolic conditions
Ronzano et al., 2021)
