This brief examines the financialized business model of Novo Nordisk and Eli Lilly for the leading GLP-1 products Ozempic, Rybelsus, and Wegovy (semaglutide) and Mounjaro and Zepbound (tirzepatide)
Consistent with this notion, we observed an upregulation of the required enzymatic machinery for local processing of GLP-1 including Glp1r, Pcsk1 and Dpp4 mRNAs in the OB of obese mice compared to lean mice
If weight loss feels harder after 40, youre not imagining it
Thus, inadequate payer coverage will have a disproportionate impact on those demographics with greater obesity prevalence and lower incomes, further driving health inequity
Complementary Peptide Therapies in the GLP-1 Era As GLP-1 therapies (both injectable and oral) become the pharmacological foundation of metabolic disease management, complementary peptide therapies address aspects of health that GLP-1 alone doesn't fully cover
Understanding how these treatments interact with hypertension helps patients and clinicians optimise both diabetes control and cardiovascular risk reduction
