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This represents a patient-specific clinical trial-on-chip (CToC) capable of providing an accurate individual drug response prediction without relying on a trial and error approach, thereby reducing healthcare costs and improving therapeutic efficacy

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designed a US-triggered MnWO X nanosystem modified with PEG (termed MnWO X -PEG) to endow the capability of GSH-enhanced ROS ( 1 O 2 and OH) production for killing malignant tumors (Figure 6D) ( X -PEG exhibited significantly time-dependent GSH consumption capacity through reducing W 6+ to W 5+ (Figure 6E), cooperating with increased ROS to achieve a powerful inhibition effect on tumors (Figure 6F)

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Kowdley 4 , Lois Lee 5 , Amnon Schlegel 6 , Hiba Graham 6 , Lu Zhang 6 , Kerry Russell 6 and Naim Alkhouri 7 , (1)University of California, San Diego, San Diego, CA, (2)Houston Research Institute, Houston, TX, (3)Texas Liver Institute, University of Texas Health San Antonio, San Antonio, TX, (4)Swedish Medical Center, Seattle, WA, (5)Terns Pharma, San Diego, CA, (6)Terns Pharma, Foster City, CA, (7)Arizona Liver Health, Phoenix, AZ Background: Non-invasive tests (NITs) have become essential to help diagnose and stage nonalcoholic steatohepatitis (NASH)

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