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This naturally occurring peptide complex combines glycine, histidine, and lysine with copper ions

However, the expression of Klotho and autophagic activity were remarkably suppressed in DKD mice and renal proximal tubule cells exposed to high glucose ( Autophagy dysregulation is involved in the pathophysiology of DKD by increasing ROS production, mediating inflammatory responses and inducing renal cell damage and apoptosis ( 3.8.3 Pyroptosis Pyroptosis is a novel type of PCD, distinct from apoptosis and autophagy

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