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To use incretins therapeutically, they would have to be injected continuously (Nauck et al., 1996)

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Obesity can affect the risk of all those conditions, and in each case except for heart failure, the statistical significance threshold was reached

Safe use requires routine monitoring of weight, A1C, renal function, and AEs, particularly during dose escalation

Notably, a 2020 clinical trial involving patients with nonalcoholic steatohepatitis (NASH) revealed a 15% incidence of tumors (benign, malignant, or unspecified) (35/239) among those administered semaglutide, compared to 8% (6/80) in the control group [108]

Mixing them in a single solution for an extended period could lead to degradation, precipitation, or unforeseen chemical reactions that reduce their efficacy