Clinical trials cover a wide variety of therapies, drug regimes, and novel substances that may each require particular attention to monitor adverse events
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Most dosing is done in the evening, before sleep onset, because the aim is to induce sleep or promote deep sleep
In a placebo-controlled, double-blind phase I study of ascending doses of cotadutide, there were dose-dependent improvements in glycemic control and increased satiety [45]
The results of a meta-analysis indicate that GLP-1RAs can reduce major adverse cardiovascular events (MACE) such as cardiovascular death, stroke, or myocardial infarction, as well as hospital admissions for heart failure and all-cause mortality, in patients with T2D [44]
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