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5:e136907
Adv Physiol Educ 2016;40:480e90
You should attend your local eye casualty department or A&E immediately, or call NHS 111 for urgent advice
It acts through the GLP-1 receptor (GLP-1R), a G protein-coupled receptor predominantly expressed in pancreatic -cells, the gastrointestinal tract, and the central nervous system
Despite numerous studies, the causes of the obesity epidemic are still not fully understood, and traditional calorie-restricted diets still lack long-term effects ( Besides lowering blood glucose and reducing weight (incredibly visceral fat), GLP-1R agonists can also lower blood pressure, improve blood lipid disorder, and reduce fatty liver ( Given that GLP-1R agonists have superior weight loss effects and good safety, some of its products have been officially approved by FDA for chronic weight management of obese or overweight adults
In mice lacking the GLP-1R in the CNS, GLP-1R agonism does not lower body weight but its glycaemic benefits are preserved [75]
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