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This isn't a failing of the drug

There are currently three drugs available in the U.S

The experimental results showed that the average Cmax ratio was 1:2.8:6.5, and the average AUC(0-t ) ratios are 1:2.8:5.7, Cmax and AUC(0-t) increase approximately in proportion to the dose increase

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APAP levels should be obtained at least 4 hours post-ingestion and then repeated after another 4 hours if the initial measurement falls below the treatment threshold on the nomogram