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Validated immunohistochemistry has had difficulty confirming high-density GLP-1R expression in human coronary endothelium and smooth muscle, raising the possibility that the vascular effects are substantially indirect [14]

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Furthermore, in contrast to Sod3, tissue Gpx3 was predominantly detected in the insoluble protein fractions, as judged from quantitative detergent solubility profiling (QDSP) generated by Schiller et al