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HbA1c reductions that rival insulin Across the SURPASS trial program, tirzepatide reduced HbA1c by up to 2.24%, bringing many participants to levels below the diabetic threshold

Consistently, a study using a murine arterial injury model revealed that local vascular damage led to downregulation of GLP1R expression in affected vessels, suggesting that mechanical or inflammatory stimuli may alter GLP1R signaling in the vasculature [80]

A sum of all frames, filtered according to the exposure dose, in each image stack was used for further processing