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The gene expression of plasma membrane glutamate transporter SLC1A2 (EAAT2) declined with aging in mouse endothelial cells, pericytes, microglia, and neurons (Ximerakis et al., 2019), including some hypothalamic GABAergic neurons (Ximerakis et al., 2019), whereas SLC1A2 expression increased with aging in some tanycytes (Jin et al., 2025)

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The number of altered metabolites between acute patients and the R group were very similar to those of acute/HCs with 419 increased and 285 decreased metabolites ( Figure 2H )

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