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In radiation settings, upregulated expression of TLR4 enhances the sensitivity and response to Proteobacteria-derived ligands, amplifying downstream NF-B signaling and cytokine secretion (Lu et al., 2020)
Nuclear Signaling : Glutathione levels influence the activation of Nrf2, a transcription factor that upregulates longevity pathways and antioxidant enzyme production, creating a supportive cellular environment against stress
To extend this data, investigation of the effects of formononetin on IgE production by PBMCs of food-allergic patients in vitro was performed [121]