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(2010) J Biol Chem 285 : 723-730 PubMed: 19861722 Search on PubMedSearch on PubMed Central DOI: Primary Citation Related Structures: 3IOL PubMed Abstract: GLP-1 (glucagon-like peptide-1) is an incretin released from intestinal L-cells in response to food intake

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When an amylin analogue like cagrilintide is paired with a GLP-1/GIP receptor agonist, the complementary mechanisms appear to produce additive appetite suppression: cagrilintide slows gastric emptying through amylin receptor activation, while tirzepatide simultaneously boosts insulin secretion and reduces glucagon