This leads to the cleavage and translocation of AIF from the mitochondrial intermembrane space to the nucleus, phosphorylation of the histone H2A family member H2AX, mitochondrial release of the death-inducing protein Smac/direct IAP-binding protein with low PI (DIABLO), and inhibition of the anti-apoptotic protein X-linked inhibitor of apoptosis (XIAP)
Morin, a natural flavonoid, protects rats against acute cadmium-induced hepatotoxicity by restoring liver function and reducing oxidative and endoplasmic reticulum stress in a dose-dependent manner
Biochemical investigations showed a normal level of cysteinyl glycine in plasma, an abnormal urinary profile with increased excretion of cysteinyl glycine (4972 mmol/mol of creatinine) and leukotrienes with increased leukotriene D4 and complete absence of LTE4
Cell Death Differ 16:130314
In all, these experiments indicated that FAT-targeted peptides have anti-FAK biological effects, such as dose-dependent induction of apoptosis and inhibition of invasion, and offer increased selectivity compared to traditional FAK kinase domain inhibitors
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