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Alterations in the ubiquitin system are known to occur during the initiation and progression of cancer, and this knowledge is starting to be exploited for the development of novel strategies to treat cancer

ROS generation induced by HCV infection triggers anti-3-hydroxysterol 24-reductase (DHCR24) antibody production, suggesting that DHCR24 may be used as a prognostic biomarker for hepatitis C progression to hepatocellular carcinoma 56,97

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Unsurprisingly, we found that the putative oxyanion hole, formed by the NH backbone of V12, could be provided by other amino acid residues