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This can be done using specific tools, such as the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I tool), as recommended by the Cochrane group

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They cite as concerns the possibility of a benign growth transforming into cancer, the risk of serious complications such as the cysts rupturing or causing the ovaries to twist, or misclassification of the cyst as benign by the initial ultrasound scan

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