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This interpretation is consistent with prior reports suggesting that impaired insulin signaling may contribute to the generation of GLP-1RA tolerance [39]

Effects of added l-carnitine, acetyl-CoA and CoA on peroxisomal beta-oxidation of [U-14C] hexadecanoate by isolated peroxisomal fractions

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Based on this, one may hypothesize that the zonated pericentral damage of OTA is due to lower expression of albumin in the pericentral hepatocytes as evidenced by immunostaining in the present study