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Prescribing GLP-1 drugs specifically for NASH represents off-label use

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In contrast to mice that were administered AC3174, mice that had similar reductions in body weight due to calorie restriction showed marginal reductions in LFC, suggesting that the decrease in LFC achieved by GLP-1RAs was not fully dependent on weight loss

In the pivotal STEP-1 trial, participants taking Wegovy lost an average of 14.9% of their body weight over 68 weeks

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