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Nevertheless, studies in human subjects with type 2 diabetes surprisingly showed well-preserved insulinotropic activity of both GLP-1 [736 amide] [5] and GLP-1 [736] that was accompanied by a short-term reduction in plasma glucose in the normal fasting range in patients previously characterized by persistent hyperglycemia [6,7]

To date, liraglutide, and the more effective once-weekly semaglutide, have been approved in the US and Europe for the treatment of obesity, with unprecedented weight loss of up to 1520%

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In contrast, the control group comprised patients with obesity who did not receive a GLP-1 prescription during the study timeframe