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Therefore, we conducted sensitivity analyses to determine whether baseline HbA 1c or prior metformin treatment were mediating factors

Brain Behav Immun 115:565587

Table 13: Results at Week 52 in a Trial Comparing TRESIBA to Insulin Glargine U-100 in Adult Patients with Type 2 Diabetes Mellitus Receiving Insulin Aspart at Mealtimes and OADs* Study I: TRESIBA Administered at Any Time Each Day as an Add-on to One or Two of the Following Oral Agents: Metformin, Sulfonylurea, or Pioglitazone in Adult Patients The efficacy of TRESIBA was evaluated in a 26-week randomized, open-label, multicenter trial in 447 patients with type 2 diabetes mellitus inadequately controlled on one or more oral antidiabetic agent (OADs) at baseline

The mechanism likely involves GLP-1 lowering baseline hunger while IF creates a caloric deficit structure that the medication reinforces

FEBS Lett 384:3134 Wonisch W, Schaur RJ (2001) Chemistry of glutathione

It shows what needs attention first, so the treatment path stays safer and more predictable