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Handfoot skin reactions appear more commonly with sorafenib than with sunitinib, and their severity with higher doses is a pattern found specifically in sorafenib recipients

In that sense, while still representing a challenging goal to be achieved, the identification of specific prognostic biomarkers and also those for the evaluation of therapeutic efficacy in ALS will have a fundamental role in designing and monitoring new treatment strategies in the complex scenario of the neurodegenerative process

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