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In a pooled post-hoc analysis of data obtained with liraglutide and semaglutide, a 53% lower risk was found of dementia compared with placebo
doi: 10.3389/fimmu.2020.00374 141 RamagliaVSheikh-MohamedSLeggKParkCRojasOLZandeeSet al
This action of long-acting GLP-1 RAs is primarily due to an enhanced ability to decrease fasting glucose, improve compliance [26, 27], and reduce weight (LEAD-6, DURATION-6, HARMONY-7, AWARD-6, and LIRA-LIXI studies) [2832] compared with short-acting GLP-1 RAs [28, 33, 34]
Such insights may be beneficial for optimizing the clinical application of glucagon receptor antagonism in diabetes treatment
Accumulation of amyloid-beta monomers can directly disrupt mitochondrial function resulting in reduced energy and accumulation of amyloid plaques leading to activation of inflammatory cascades [36, 37]
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