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All participants received the same intervention, and outcome assessments were performed using predefined laboratory protocols

However, attributing the intolerance to a specific agent within the combination cream remains challenging

SchweglerIvon HolzenAGutzwillerJPSchlumpfRMhlebachSStangaZ

PubMed Central , Nutrients , vol

[17] (UK sample) reporting an effect size d = 2.6 for ACC glutamate difference between 1-month remitters and nonremitters, we required a sample of at least 22 patients to demonstrate 50% of the reported effect ( d = 1.3), with 5% type 1 and 20% type 2 error rates