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It was almost a decade after the first approval in T2D, before GLP-analogs picked up a second indication in obesity

Finally, an important issue with GLP-1 receptor agonists is their potential to cause loss of lean body mass (fat-free mass)

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Contempre, B., Le Moine, O., Dumont, J

But based on what we know right now, semaglutide appears to be a safe option for long-term use, especially under the guidance of a healthcare professional

Depending on your starting point and end goal, as well as your lifestyle habits and genetics, you can expect to stay on medication for about 12 months