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[6] SAM may act as a methyl donor in the metabolic processes that control lipid homeostasis, DNA stability, gene expression, and neurotransmitter release, which may account for the benefits it confers

This topic was evaluated in two large cohort studies: in the first study, an increased risk for pancreatic cancer was observed in new users 10 , whereas no relation was observed in the second study 11

Clin Ther 37:2086-2103.e10

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