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37 Nonetheless, EAAT3 has been associated with increased chemoresistance in colorectal cancer models 38 and reported to be highly expressed in prostate cancer

Concerning the critical role of CPT1A in FAO, one study treated tubular EpiCs with the CPT1 inhibitor etomoxir, and the upregulated expression of genes related to fibrosis such as -smooth muscle actin and vimentin was observed (Kang et al., 2015)

Integrating these perspectives provides a coherent foundation for anticipating variability in treatment responses and for informing the clinical management strategies outlined in the following chapters

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