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The acidic environment inhibits the infiltration and antitumor function of natural killer (NK) cells, Dendritic cells (DCs), and CD8 + T cells [73,74,75,76,77]

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Additionally, RB1 deficiency is able to enhance tumor metastasis by increasing OXPHOS to generate more ATP fueling for tumor invasion and cooperating oncogenic alterations to uphold EMT and metastasis (232)

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doi: 10.1016/S0021-9258(18)35614-X 105 FedorowHTriblFHallidayGGerlachMRiedererPDoubleK

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[DOI] [PubMed] [Google Scholar] 76.Virmani MA, Krsmanovic LZ, Stojilkovic SS, Catt KJ

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Inhibition of mitochondrial fusion by alpha-synuclein is rescued by PINK1

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