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The steady-state 24-hour urinary glucose excretion in patients with type 2 diabetes mellitus and mild, moderate, and severe renal impairment was 42%, 80%, and 90% lower, respectively, than in patients with type 2 diabetes mellitus with normal renal function

A perspective published in Cell highlights emerging outcomes of tau-targeting approaches with disease-modifying potential and provides a framework for next-generation AD and tau-therapy development toward increasingly efficient disease-halting interventions

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This applies to both compounds, but it is especially critical for tirzepatide where dose escalation directly impacts GI tolerability

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Jardiance primarily works through the kidneys, but it is not generally considered harmful to them when prescribed appropriately