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87 In addition, as shown in a recent study on allosteric communications in antibodyantigen recognition and FcR activation, 97 more effective IC constructs may be generated

In trials with patients with type 2 diabetes and overweight/obesity, after 16 weeks of treatment with Danuglipron, the high-dose (120 mg twice daily) group showed an average weight loss of 4.2 kg and a reduction in HbA1c levels by 1.2% compared to the placebo group

Interestingly, no difference in food intake was observed between wild-type mice treated with the dual incretin GLP-1/GIP coagonist and those treated with the tri-agonist despite the difference in weight loss, and this was found to be due to significantly higher ATP expenditure in tri-agonist-treated diet-induced obese mice

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