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Here we show how G49, an oxyntomodulin (OXM) analog and dual glucagon/glucagon-like peptide-1 receptor (GCGR/GLP-1R) agonist, triggers an inter-organ crosstalk between adipose tissue, pancreas, and liver which is initiated by a rapid release of free fatty acids (FFAs) by white adipose tissue (WAT) in a GCGR-dependent manner

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Mounjaro (tirzepatide) is a dual GIP and GLP-1 receptor agonist that reduces appetite by slowing gastric emptying and influencing brain appetite centres

Together, these results reveal the impact of GLP-1R deletion on functional connectivity throughout the brain and further highlight the importance of GLP-1R in brain networks

The Y5 receptor mediates the effects of NPY-induced food intake, with selective agonism of this receptor, resulting in stimulation of feeding (105)