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In topical application, studies use concentrations of 0.01-1% in cream or serum formulations (Pickart et al., BioMed Res Int 2015For subcutaneous injection (research), doses vary depending on the experimental model

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Peripherally administered GLP-1 thus indirectly activates neurons of the amygdala

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Your cells become "deaf" to insulin's signals, so your body pumps out more and more insulin to compensate