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The receptor is closely associated with ghrelin
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In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis
Preclinical studies have also revealed that dual agonists of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR) have synergistic anti-inflammatory and neuroprotective effects, suggesting the potential advantages of multitargeting strategies (Yuan et al., 2024)
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