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Moreover, in humans, sDPP-4 appeared to increase obesity and insulin resistance, but it was not associated with systemic metabolic inflammation (IL-6 or CRP levels), evidencing the complexity of the role of sDPP-4 in the inflammatory processes [64]

Abstract In healthy humans, the incretin glucagon-like peptide 1 (GLP-1) is secreted after eating and lowers glucose concentrations by augmenting insulin secretion and suppressing glucagon release

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Wade JR, Parker G, Kosutic G, Feagen BG, Sandborn WJ, Laveille C, et al

GLP-1 receptor agonists are a class of medications that mimic the glucagon-like peptide-1 hormone, enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying to lower blood glucose levels