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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition
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NNMT sits between NAD+ metabolism and one-carbon methylation metabolism, pathways that support redox reactions, DNA repair, and transcriptional regulation
[DOI] [PubMed] [Google Scholar] 36.Alston TA, Abeles RH
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