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Since the concentration of antioxidants is low in the sperm cytoplasm, protection against ROS is provided by GPx5 only (Taylor et al

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Even when GLP-1 analogs or modified forms of GLP-1 can escape DPP-4 attack, they remain prone to renal elimination given GLP-1's small molecular size (~3.4 kDa) [13], providing a second means by which GLP-1's plasma half-life is limited

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