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People taking semaglutide for weight loss continued to consume significantly fewer calories after 60 weeks on the medication, helping explain how the medication supports both initial weight loss and long-term weight maintenance

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Activation of these receptors can influence mood pathways, and rapid metabolic changes from weight loss trigger secondary stress responses that may amplify emotional sensitivity in susceptible individuals

Why This Research Matters For people taking semaglutide, understanding its effects on mood is important