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The Neh4 and Neh5 domains are two important transactivation domains

Alternative RNA processing of the primary transcript by inclusion of exons 1 to 4 with polyadenylation following exon 4 (encoding calcitonin) produces a mRNA that encodes the precursor for calcitonin

Reproductive toxicity studies of acetylcysteine in the rat given oral doses of acetylcysteine up to 1,000 mg/kg (5.2 times the human mucolytic dose) have also been reported in the literature.1 The only adverse effect observed was a slight non-dose-related reduction in fertility at dose levels of 500 or 1,000 mg/kg/day (2.6 or 5.2 times the human mucolytic dose) in the Segment I study

Yang et al., Reprod Biol Endocrinol 2019

And then there's some early signs, but I think it's still a lot to be proven around thyroid cancer