By understanding how GLP-1RAs influence mitochondrial function and stress responses in the eye, researchers can identify pathways and biomarkers that are also relevant in the heart, brain or other organs, and vice versa , promoting broader therapeutic applications and potentially reducing the time and cost of developing treatments for complex, multi-organ diseases
Pharmacol Ther 2008;118: 25067
In the peroxisome proliferator-activated receptor (PPAR)-induced COPD model, upregulation of GPX3 expression can reduce lung tissue damage caused by oxidative stress ( As mentioned earlier, the vast majority of GPX3 is secreted by the renal proximal convoluted tubules, so we speculate that the kidney may be a highly expressed organ of GPX3, and to test our hypothesis, we analyzed the GSE111159 dataset (This dataset mainly detects the gene sequencing of 10 tissues and organs of mouse kidney, liver, brain, lung, thymus, muscle, spleen, stomach, heart and testicle under physiological conditions to understand the gene expression of each tissue and organ) in the GEO database (Gene Expression Omnibus, We found that GPX3 had the highest level of expression in kidney tissue under mouse physiology (Figure 3A), which is consistent with the results of the analysis by Kim et al
doi: 10.1289/ehp.1205063 107 CimminoIFioryFPerruoloGMieleCBeguinotFFormisanoPet al
Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium
Vitamin B12 deficiency is a common issue in India, affecting around 50% of the population