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Such multifaceted benefits have expanded GLP-1RAs therapeutic scope to neurodegenerative, cardiovascular, and chronic kidney disease, etc
Triple GLP-1/GIP/Glucagon Agonists The Next Generation of Anti-Obesity Drugs
10.1016/j.redox.2024.103129 42 LiddelowS
Tolerability issues such as gastro-intestinal side effects were also cited as a common reason, accounting for around 15% of discontinuations
These are generally mild and self-limiting
Inhibiting RHOA signaling in mice increases glucose tolerance and numbers of enteroendocrine and other secretory cells in the intestine
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