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They are smaller than proteins but larger than individual amino acids, typically containing 2 to 50 amino acid units

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Pretorius E, Venter C, Laubscher GJ, Lourens PJ, Steenkamp J, Kell DB

Other studies have found similar patterns

However, if the medication is being prescribed for a covered condition (type 2 diabetes), coverage may still be possible

The classic approach to address this issue by a medicinal chemist is often to use a prodrug approach by connecting a brain targeting ligand to a drug molecule to form a prodrug and the drug is released after the prodrug enters the brain