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IGF-I levels decline with age, mainly due to reduced GH secretion and not increased GH resistance

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The compound's place in the broader peptide research landscape is distinctive: it is as much a coordination compound as it is a peptide, and most of its biology depends on the copper that the peptide carries

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GLP-1RAs have demonstrated beneficial actions in the setting of acute myocardial infarction 20,103110 , heart failure with reduced ejection fraction (HFrEF) in both lean and obese 111 , in atherosclerosis 112114 , and peripheral artery disease 115,116