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Kidney and heart problems

Pavlidou E, Papadopoulou SK, Fasoulas A, Papaliagkas V, Alexatou O, Chatzidimitriou M, et al

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Specifically, the enzyme sulfotransferase (SULT1A1) converts minoxidil into minoxidil sulfate within hair follicles

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Ang II treatment reduces the ABCG1 (an important molecule associated with cholesterol homeostasis) expression, and the overexpression of SIRT6 improves Ang II-induced lipid droplet formation, cholesterol accumulation, and cholesterol efflux capacity, restoring ABCG1 expression, further affecting ABCG1-mediated cholesterol efflux to ameliorate Ang II-induced podocyte injury (Yang et al., 2020)