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Another study using the CIA mouse model also suggested that Clostridium cluster XIVa can activate transforming growth factor- (TGF-), thereby enhancing the immunosuppressive function of Tregs (125)
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Frontiers in Pharmacology , 11, 592345
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The NRF2 protein isoforms encoded by these splice variants lack the KEAP1 interaction domain, thus preventing NRF2 degradation and resulting in protein stabilization and transcription of NRF2 target genes [183]
