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10.8%, RR 4.44, 95% CI: 1.6112.21) and live birth rate (40.0 vs

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Studies have shown that PICs can directly bind directly to glutamate receptors on neurons, thereby enhancing synaptic excitability, and promoting both central sensitization and NPP development ( Beyond direct regulation of neuronal excitability via synaptic plasticity, PICs can also enhance neuronal excitability by activating glial cells and promoting A1 (astrocytic) or M1 (microglial) polarization, leading to further release of pro-inflammatory cytokines

Epub 2009 Feb 26