The key strategies for minimizing regain during a short break include maintaining a high protein intake of 1.6-2.2 grams per kilogram of body weight daily, continuing or increasing resistance training to preserve muscle mass, planning meals in advance so hunger does not drive impulsive food choices, monitoring weight weekly but not daily to avoid overreacting to normal fluctuations, and staying hydrated since the body may retain more water without GLP-1 mediated effects on fluid balance
A phase 2 clinical trial, published in The New England Journal of Medicine, included 338 adults with a body mass index (BMI) of 30 or greater, or a BMI between 27 and 30, with at least one weight-related comorbidity to assess the efficacy and benefits of retatrutide
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GLP-1 receptor agonists such as semaglutide work by stimulating the pancreas to release insulin when blood sugar levels rise, while also reducing the levels of glucagon, a hormone that increases blood sugar