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Topical metformin 30% lotion twice daily was compared with TC for 8 weeks in a randomized controlled study involving 40 Egyptian patients with melasma

A systematic review analyzing multiple clinical trials confirmed that oral glutathione at doses of 250-500mg showed a significant reduction in melanin index compared to placebo over 8-12 weeks

Cystathionine is then hydrolyzed by cystathionine -lyase to form -ketobutyrate and free cysteine, which may be used for GSH formation (56, 119, 306)

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