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Many patients are concerned about the possibility of a scar such as this forming after a surgery or injury due to the more noticeable nature of a keloid

Keep it away from direct sunlight and moisture

This can manifest as diffuse darkening across the lip surface but also as localized dark spots, particularly on the lower lip and the vermilion border

In addition, in the case-control part we carefully matched for sex, age as well as geographic region and used multivariable analysis to further adjust for potential confounders such as physical activity, levels of education and smoking status